Bin HeGo to Blog

Hi, this is Bin Z. He (何斌). Welcome to my academic website. I am an evolutionary & molecular biologist working at Harvard University, in the lab of Dr. Erin O’Shea. I employ genetics, molecular biology and systems biology approaches to understand how gene regulatory networks evolve between species, its contribution to species adaptation, and how natural selection acts in this process. My current research uses yeast stress response pathways as a model, to learn the principles in regulatory evolution and its role in assisting a commensal yeast adapting to the host environment. My past research has focused on the role of natural selection in transcription factor binding sites evolution in Drosophila enhancers [1], and a novel approach to identify natural variation that modifies a Mendelian disease phenotype in a fly model [2]. These two projects were completed during my Ph.D. training with Dr. Marty Kreitman in the Department of Ecology and Evolution at The University of Chicago.

Enjoy and your comments are most welcome!

O’Shea lab website
Kreitman lab website
Google Scholar page

email: binhe_at_fas#harvard#edu


[1] He, B. Z., Holloway, A. K., Maerkl J. S., Kreitman, M. (2011) Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modules. PLoS Genet 7(4), e1002053.

[2] He, B.Z., Ludwig, M.Z., Dickerson, D.A., Barse, L., Arun, B., Vilhjálmsson, B.J., Pengyao Jiang, Park S.Y., Tamarina, N.A., Selleck S.B., Wittkopp P.J., Bell, G.I., Kreitman, M. (2013) A Drosophila Model to Investigate Natural Variation Effect in Response to Expression of a Human Misfolded Protein. Genetics 196 (2), 557-567